Integrated Optimization of Upstream and Downstream Processing in Biopharmaceutical Manufacturing under Uncertainty: A Chance Constrained Programming Approach
نویسندگان
چکیده
منابع مشابه
Chance constrained programming approach to process optimization under uncertainty
Deterministic optimization approaches have been well developed and widely used in the process industry to accomplish off-line and on-line process optimization. The challenging task for the academic research currently is to address large-scale, complex optimization problems under various uncertainties. Therefore, investigations on the development of stochastic optimization approaches are necessi...
متن کاملSupply Chain Planning under Uncertainty: A Chance Constrained Programming Approach
Uncertainty issues associated with a multi-site, multi-product supply chain planning problem has been analyzed in this paper using the chance constraint programming approach. In literature, such problems have been addressed using the two stage stochastic programming approach. While this approach has merits in terms of decomposition, computational complexity even for small size planning problem ...
متن کاملProcess Optimization and Control under Uncertainty: a Chance Constrained Programming Approach
A novel chance constrained programming approach for process optimization of large-scale nonlinear dynamic systems and control under uncertainty is proposed. The stochastic property of the uncertainties is explicitly considered in the problem formulation in which some input and state constraints are to be complied with predefined probability levels. This incorporates the issue of feasibility and...
متن کاملChance Constrained Batch Distillation Process Optimization under Uncertainty
Uncertainties may have a large impact on equipment decisions, plant operability, and economic analysis. Thus the consideration of uncertainties in optimization approaches is necessary for robust process design and operation. As a part of it, efficient chance constrained programming has become an important field of research in process systems engineering. In this work, a new approach is proposed...
متن کاملDATA ENVELOPMENT ANALYSIS WITH FUZZY RANDOM INPUTS AND OUTPUTS: A CHANCE-CONSTRAINED PROGRAMMING APPROACH
In this paper, we deal with fuzzy random variables for inputs andoutputs in Data Envelopment Analysis (DEA). These variables are considered as fuzzyrandom flat LR numbers with known distribution. The problem is to find a method forconverting the imprecise chance-constrained DEA model into a crisp one. This can bedone by first, defuzzification of imprecise probability by constructing a suitablem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Industrial & Engineering Chemistry Research
سال: 2016
ISSN: 0888-5885,1520-5045
DOI: 10.1021/acs.iecr.5b04403